学校主页    中文  
HomePage- Research Team- PI Introduction
更多

PI Introduction

Xinwei Hua

日期：2024-12-17 | 访问量：

                                                                                               花欣炜-缩小.jpg


Xinwei Hua, PhD, MPH

Investigator/Assistant Professor of Epidemiology

Department of Cardiology

Peking University Third Hospital

Peking University Health Science Center

National Key Laboratory of Vascular and Reconstructive Diseases

xhua@bjmu.edu.cn



    Dr. Xinwei Hua, a molecular and cardiovascular epidemiologist, focuses on studying the molecular and clinical epidemiology of cardiometabolic diseases. By integrating electronic medical record (EMR) data with molecular profiles, her research involves the identification of novel therapeutical and gut-microbial targets for cardiometabolic disease prevention and treatment, and the development of diagnostic, phenotyping and risk assessment tools for individualized treatment for patients with heart failure with preserved ejection fraction.


Education

PhD, Epidemiology, University of Washington, 2016-2020

MPH, Epidemiology, Emory University, 2010-2012

BE, Bioengineering, South China University of Technology, 2006-2010


Research Experiences

2022/04 to Current Assistant professor, Peking University Third Hospital

2020/10 -2021/12 Postdoctoral research fellow, Mass General Hospital/ Havard Medical School

2014/09 -2020/10 Research associate, Fred Hutchinson Cancer Research Center


Research interests

o Drug, gut microbiome and cardiometabolic disease (CMD)

o Molecular profiling, phenotyping of heart failure with preserved ejection fraction

o Diagnostic, phenotyping and risk assessment tools for CMD


Publications

  1. Hua X, McGoldrick J, Nakrour N, et al. Gut microbiome structure and function in asymptomatic diverticulosis. Genome Med 2024;16(1):105. [IF: 10.3, JCR Q1]

  2. Hua X#*, Ungaro RC#*, Petrick LM, Chan AT, Porter CK, Khalili H (2023), Inflammatory Bowel Disease is Associated with Prediagnostic Perturbances in Metabolic Pathways, Gastroenterology, 164.1: 147-150. [IF: 29.4, JCR Q1]

  3. Zhou Q, Yang J, Wang W, Shao C, Hua X*, Tang YD* (2023). The Impact of the Stress Hyperglycemia Ratio on Mortality and Rehospitalization Rate in Patients with Acute Decompensated Heart Failure and Diabetes. Cardiovascular Diabetology 22 (1): 189. [IF: 9.3, JCR Q1]

  4. Zhou Q, Yang J, Tang H, Guo Z, Dong W, Wang Y, Meng X, Zhang K, Wang W, Shao C. and Hua X*, Tang YD* (2023). High triglyceride-glucose (TyG) index is associated with poor prognosis of heart failure with preserved ejection fraction. Cardiovascular Diabetology, 22(1): 263. [IF: 9.3, JCR Q1]

  5. Fuller H, Zhu Y, Nicholas J, Chatelaine HA, Drzymalla EM, Sarvestani AK, Julián-Serrano S, Tahir UA, Sinnott-Armstrong N, Raffield LM, Rahnavard A, Hua X, Shutta KH, Darst BF (2023). Metabolomic Epidemiology Offers Insights into Disease Aetiology. Nature Metabolism 5 (10): 1656–72. (IF=20.8, JCR Q1)

  6. Joshi AD, Rahnavard A, Kachroo P, Mendez KM, Lawrence W, Julián-Serrano S, Hua X, Fuller H, Sinnott-Armstrong N, Tabung FK, Shutta KH, Raffield LM, Darst BF, COMETS Early Career Scientist Working Group. (2023). An Epidemiological Introduction to Human Metabolomic Investigations. Trends in Endocrinology and Metabolism: TEM 34 (9): 505–25. [IF=10.9, JCR Q1]

  7. Hua X, Lopes EW, Burke KE, Ananthakrishnan A, Rtchter J, Lo CH, Lochhead P, Chan AT, Khalili H (2022), Smoking behavior changes after diagnosis of inflammatory bowel disease and risk of all-cause mortality, Journal of Crohn’s and Colitis, 16(7):1030-1038. [IF: 10.02, JCR Q1]

  8. Hua X#, Cao Y#, Morgan DM, Miller K, Chin SM, Bellavance D, Khalili H (2022), Longitudinal analysis of the impact of oral contraceptive use on the gut microbiome, Journal of Medical Microbiology, 71(4), 001512. [IF: 3.196, JCR Q4]

  9. Huang Y, Hua X*, Labadie JD, Harrison TA, Dai J, Lindstrom S, Lin Y, Berndt SI, Buchanan DD, Campbell PT, Casey G, Gallinger SJ, Gunter MJ, Hoffmeister M, Jenkins MA, Sakoda LC, Schoen RE, Diergaarde B, Slattery MI, White E, Giles GG, Brenner H, Chang-Claude J, Joshi AD, Ma W, Pai RK, Chan AT, Peters U, Newcomb PA* (2022). Genetic variants associated with circulating C-reactive protein levels and colorectal cancer survival: Sex- and lifestyle factors- specific associations, International Journal of Cancer, 150(9):1447-1454. [IF: 7.316, JCR Q1]

  10. Hua X, Kratz M, Malen R, Dai J, Lindstroem S, Zheng Y, Newcomb PA (2021). Associations between post-treatment inflammatory biomarkers and survival among stage II-III colorectal cancer patients, British Journal of Cancer, 125, 806–815. [IF: 9.075, , JCR Q1]

  11. Hua X, Dai J, Lindstrom S, Harrison TA, Lin Y, Alberts SR, Alwers E, Berndt SI, Brenner H, Buchanan DD, Campbell PT, Casey G, Chang-Claude J, Gallinger SJ, Giles GG, Goldberg RM, Gunter MJ, Hoffmeister M, Jenkins MA, Joshi AD, Ma W, Milne RL, Murphy N, Pai RK, Sakoda LC, Schoen RE, Shi Q, Slattery MI, Song M, White E, Le Marchand L, Chan AT, Peters U, Newcomb PA (2021). Genetically predicted circulating C-reactive protein and colorectal cancer survival: A Mendelian randomization study, Cancer Epidemiology, Biomarkers, and Prevention, 30 (7): 1349–1358. [IF: 4.09, JCR Q2]

  12. Hua X, Newcomb PA, Chubak J, Malen RC, Ziebell R, Kamineni A, Zhu LC, Upton MP, Wurscher MA, Thomas SS, Newman H, Hardikar S, Burnett-Hartman AN (2020). Colorectal serrated polyp molecular characteristics associated with subsequent advanced colorectal neoplasia. Cancer Causes and Control, 31(7):631-640. [IF: 2.53, JCR Q2]

  13. Zheng Y, Hua X, Win AK, MacInnis RJ, Gallinger S, Marchand LL, Lindor NM, Baron JA, Hopper JL, Dowty JG, Antoniou AC, Jenkins MA, Newcomb PA (2020). A new comprehensive colorectal cancer risk prediction model incorporating personal characteristics, family history, and environmental factors. Cancer Epidemiology, Biomarkers, and Prevention, 29(3), 549-557. [IF: 4.09, JCR Q2]

  14. Penney KL, Banbury BL, Bien S, Harrison TA, Hua X, Phipps AI, Sun W, Song M, Joshi AD, Alberts SR, Allegra CJ, Atkins J, Colangelo LH, George TJ, Goldberg RM, Lucas PC, Nair SG, Shi Q, Sinicrope FA, Wolmark N, Yothers G, Peters U, Newcomb PA, Chan AT (2020). Genetic Variant Associated with Survival of Patients with Stage II-III Colon Cancer. Clinical Gastroenterology and Hepatology. 18(12):2717-2723.e3. [IF: 13.576, JCR Q1]

  15. Hua X, Phipps AI, Burnett-Hartman AN, Adams SV, Hardikar S, Cohen SA, Kocarnik JM, Ahnen DJ, Lindor NM, Baron JA, and Newcomb PA (2017), Timing of aspirin and other nonsteroidal anti-inflammatory drug use among patients with colorectal cancer in relation to tumor markers and survival, Journal of Clinical Oncology, 35, 2806-2813. [IF: 50.717, JCR Q1]

  16. Kocarnik JM, Hua X, Hardikar S, Robinson J, Lindor NM, Win AK, Hopper JL, Figueiredo JC, Potter JD, Campbell PT, Gallinger S, Cotterchio M, Adams SV, Cohen SA, Phipps AI and Newcomb PA (2017). Long-term weight loss after colorectal cancer diagnoses is associated with lower survival: The Colon Cancer Family Registry, Cancer, 123(23): 4701-4708. [IF: 6.92, JCR Q1]

  17. Hua X, Ward, KC, Gillespie, TW, Lipscomb J, Goodman M (2014). Non-small cell lung cancer treatment receipt and survival among African Americans and whites in a rural area, Journal of Community Health, 39(4), 696-705. [IF: 4.371, JCR Q2]