Yuxuan Guo, PhD，

Assistant Professor/Principal Investigator

School of Basic Medical Sciences

Institute of Cardiovascular Sciences

State Key Laboratory of Vascular Homeostasis and Remodeling

Beijing Key Laboratory of Cardiovascular Receptors Research

Peking University Health Science Center

Email：guo@bjmu.edu.cnEducation

2006.9-2010.7     Peking University  BS

2010.8-2015.8    The Johns Hopkins University  PhD

2015.9-2020.11    Boston Children’s Hospital  Postdoc

Funding

2020 NIH pathway to independence award (K99)

2021-2024 Beijing Nova Program

2022-2024 the National Natural Science Foundation of China

2022-2025 the National Natural Science Foundation of China  

2022-2027 the National Key R&D Program of China

2023-2025 the National Natural Science Foundation of China  

Recent Publication（#First author, *Corresponding author）：

1. Sun Y, Guo C, Chen Z, Lin J, Yang L, Zhang Y, Wu C, Zhao D, Jardin B, Pu WT, Zhao M, Dong E, Hu X, Zhang S*, Guo Y*. Non-Cell-Autonomous Cardiomyocyte Regulation Complicates Gene Supplementation Therapy for Lmna-Associated Cardiac Defects in Mice. JACC Basic Transl Sci. 2024 Aug 21;9(11):1308-1325.

2. Guo CT, Jardin BD, Lin JS, Ambroise RL, Wang Z, Yang LZ, Mazumdar N, Lu FJ, Ma Q, Cao YP, Liu CZ, Li KL, Liu XJ, Lan F, Zhao MM, Xiao H, Dong ED, Pu WT*, Guo YX*. In vivo proximity proteomics uncovers palmdelphin (PALMD) as a Z-disc-associated mitigator of isoproterenol-induced cardiac injury. Acta Pharmacol Sin. 2024

3. Yang L#, Liu Z#, Chen G, Chen Z, Guo C, Ji X, Cui Q, Sun Y, Hu X, Zheng Y, Li Y, Gao F, Chen L, Zhou P, Pu WT, Guo Y*. MicroRNA-122-Mediated Liver Detargeting Enhances the Tissue Specificity of Cardiac Genome Editing. Circulation. 2024

4. Yang L#, Liu Z#, Sun J#, Chen Z#, Gao F*, Guo Y*. Adenine base editor-based correction of the cardiac pathogenic Lmna c.1621C > T mutation in murine hearts. J Cell Mol Med. 2024

5. Yang L, Sun J, Chen Z, Liu L, Sun Y, Lin J, Hu X, Zhao M, Ma Y, Lu D, Li Y*, Guo Y*, Dong E. The LMNA p.R541C mutation causes dilated cardiomyopathy in human and mice. Int J Cardiol. 2022