Independent PI of the State Key Laboratory of Vascular Homeostasis and Remodeling and the Department of Integration of Chinese and Western Medicine, Peking University Health Science Center

    Dr. Feng got the Doctor degree in Human Physiology from Peking University in 2009. Subsequently, she entered the Department of Physiology and Pathophysiology of Basic Medical School of Peking University as an assistant researcher and then associate researcher. In 2022, she transferred to the Department of Integration of Chinese and Western Medicine of Peking University as an associate researcher. Her research focuses on metabolic vascular injury and repair mechanisms and intervention strategies. The innovation lies in: (1) Mapping the cell types of the inflammatory immune microenvironment caused by Hcy, a new risk factor for vascular injury, discovering the specific regulatory mechanisms of the inflammatory immune microenvironment, and revealing the intercellular interactions mediated by active lipid molecules, pathogenic antibodies and inflammatory cytokines. Meanwhile, lineage tracing mice (Gift from Professor Qingbo Xu, Zhejiang University) were used to identify new pro-regenerative fibroblasts with repair potential, which expanded the origin of CD34+ stem cell for fibroblasts. The important scientific problems related to vascular diseases caused by cell-cell dialogue and vascular damage - repair homeostasis imbalance are described. (2) To reveal a new mechanism for the regulation of inflammatory immune cell activation, and confirm that Hcy, as an amino acid, regulates the mitochondria-endoplasmic reticulum dialogue and initiates REDOX imbalance, and then promotes the phospholipid oxidation modification of cell membranes, resulting in impaired cell function. It deepened the understanding of the regulation of cell function by active lipid molecules; (3) Confirmed that correcting the inflammatory immune microenvironment and the "damage - repair imbalance" is a new intervention strategy for vascular diseases. The series of research achievements have been positively cited by authoritative journals, and won the "Wiley China Open Science Outstanding Contribution Author" in 2023. As responsible or first author (including co-author), 24 research papers were published in various authorative journals, such as Signal Transduct Target Ther, Protein & Cell, Circ Res, Sci Adv, Cardiovasc Res, Redox Biol. Undertaken more than 10 projects, including the National Natural Science Foundation major research program cultivation project/General project/Youth project, and so on.

Email：juanfeng@bjmu.edu.cn